The show centers on a wealthy video game-producing family and the unexpected murder of the patriarch, Boris Carlisle, who is in control of the company. A widower with four children (Natalia, Dmitri, Ivan and Sasha), Carlisle exhibits an irrational and unconcealed hatred (for apparently misogynistic reasons) for daughter Natalia, the sole Carlisle child interested in the success of the family's video game business, the titular Spyder Games. Carlsle instead places all of his interest and value in Dmitri, the oldest son, while second son Ivan's sensitivity is rewarded with Carlisle's barely concealed contempt. Youngest son Sasha, a teen much younger than his siblings, is superficially indulged.
Dmitri becomes romantically involved with Daphne, a fashion designer, but through mistaken identity is deceived into having sex with Daphne's conniving employee Taylor. Concealing a trailer trash past while working secretly as a call girl, Taylor then supposedly becomes pregnant with Dmitri's child. Ivan marries Julie Whitmore, the daughter of another wealthy local businessman, but then reveals he is gay as he is undeniably attracted to Francisco, a male houseguest in the Carlisles' home and one-time flame of Natalia's. Sasha pursues a career as a serious musician but is frustrated at being typecast as a teen idol in the style of Aaron Carter; indifferent and easily distracted, he breaks the heart of Cherish, a high school classmate with a hard crush on him who is also his most loyal fan. Meanwhile, Natalia struggles to conduct business at Spyder Games, constantly opposed and undermined by her father, who demonstrates many unscrupulous behaviors, both personal and professional. A host of additional characters move in and out of the Carlisles' dealings, including private investigator Jeff Northcutt, Taylor's ex-convict brother Lyle and Natalia's creepily devoted lackey Todd. Eventually Sasha is revealed to be Natalia's son instead of brother, fathered by Ivan's wife Julie's father when Natalia was about thirteen years old. As the episodes progress, a mysterious series of events lead to Boris' murder and the discovery of his severed head in a freezer.